The Ultimate Guide to Seamlessly Incorporating Tretinoin into Your Skincare Routine—Without Disrupting Your Entire Regimen

The Ultimate Guide to Incorporating Tretinoin into Your Skincare Routine—Effortlessly Enhancing Your Regimen

Marie Kouadio Amouzame

It takes years to cultivate a skincare routine. And when it comes to taking things to the next level, the best approach is to ask your dermatologist for treatments tailored to your skin. But taking home a prescription is one thing—effectively incorporating it into your skincare habits is another. If you’ve ever put out a Google search wondering “how to use tretinoin,” don’t worry—you’re definitely not alone.

Crafting a skincare routine can be a messy art. Trial, error, trial, (more error), then finally, you have a set of products that work. Until… they don’t. Whether you’re greeted with an unexpected breakout or tempted by a shiny new product, that carefully curated selection on your top shelf is bound to shift.

With new skin concerns come new ingredients that force you to change up your whole regimen. Enter: the tricky dance of learning how to use tretinoin in your skincare routine.

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How to Use Tretinoin—and Reap the Glowy Benefits

Tretinoin is the most popular prescription retinoid—and for good reason. It’s effective, comes in different concentrations to tackle different concerns, and is a more targeted treatment than over-the-counter retinol. If you’ve tried your hand at retinol night creams but are still looking to fade hyperpigmentation, fight acne, and reduce signs of aging, tretinoin might just be for you. But to get the most out of it, it’s best to tailor the rest of your routine to prep your skin for your tretinoin journey.

Maybe it’s just me, but I always answer the call of a buzzy new ingredient, a well-packaged aesthetic, and the latest luxury holy grail. My routine has mostly been the same for the past few years, but I make a few exceptions. And to be totally honest, I barter with myself. If I finish one bottle of vitamin C, I let myself buy a replacement from the newest brand I’ve been eyeing on Instagram. Or, when the seasons change, I make an effort to mix things up. Exfoliating masks and collagen body creams in the winter, dewy serums and sunscreen in the spring, and so on.

But it’s not just my temperaments and whims that cause my skincare to shift and sway. Over the years, I’ve learned to listen to my skin. I calm down my routine when it gets overwhelmed, and I step it up when I break out. So, if you’re wondering how to use tretinoin, listening to your skin is paramount to avoid peeling and skin irritation.

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What is tretinoin?

Tretinoin is a derivative of vitamin A, aka a retinoid. Tretinoin usually comes in a gel or cream form. Less commonly, it can also be applied topically in its liquid form or even taken orally. It’s one of the most popular ingredients in prescription-strength acne treatments. Like other retinols, tretinoin also helps fade fine lines and hyperpigmentation. Unlike retinols you’re familiar with, tretinoin is much stronger. So much so that it’s only available with a prescription.

Tretinoin cream and gel typically comes in three concentrations: 0.025%, 0.05%, and 0.1%. 0.025% is the mildest and is generally prescribed for overall skin improvement or mild acne. 0.05% is usually prescribed for anti-aging and reducing fine lines and wrinkles. 0.1% is the highest concentration and should be used with caution. Usually prescribed for people who already have experience with retinoids, it’s used for severe cases of acne, melasma, deep wrinkles, and fine lines. Your healthcare professional can help you decide the strength that fits your needs best.

What effect does tretinoin have on the skin?

Tretinoin accelerates cell turnover. But so do over-the-counter retinol creams. So what’s the difference between tretinoin and retinols you can find in your drugstore beauty aisle? Potency. For any vitamin A derivative to work, your skin needs to convert it to retinoic acid. I’ll spare you too much of the science, but tretinoin is stronger because it’s already in the form of retinoic acid. This means your skin doesn’t have to waste time converting it, and it can get right to work.

Because of its strength, tretinoin works faster than OTC retinols. It stimulates cell generation, sloughs away dead skin cells, and sweeps away bacteria from your pores. Additionally, studies show tretinoin helps stimulate collagen production and block acne-causing inflammatory pathways. Combined, this makes it a powerful acne fighter. It has also been FDA-approved for signs of photoaging, like fine lines and dark spots. Overall, it’s a highly effective ingredient for clearer, smoother, more even skin.

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Who is a candidate for tretinoin?

Tretinoin is only available with a doctor’s prescription, so consult a dermatologist if you’re looking to add it to your routine. Your skin type and concerns will determine if tretinoin is right for you. If you’re looking to address fine lines, dark spots, severe acne outbreaks (including cystic acne), and skin texture concerns, tretinoin might be an effective treatment.

To be a good candidate, you also have to have really resilient skin. This means pretty much no sensitivity at all. Most experts recommend starting with an OTC retinol to see how your skin reacts. Tretinoin doesn’t have to be your first choice. Starting with milder retinol might address your concerns. It’s also better suited for people with indented acne scars, severe melasma, or hyperpigmentation. Or, if you’re over 35 and looking to reverse sun damage and signs of aging, tretinoin might be a good option.

As a stronger retinoid, tretinoin is probably not right for anyone who has any degree of sensitive skin. A history of eczema, rosacea, or frequently irritated skin also points to a delicate skin barrier, which tretinoin could compromise further. It’s also probably best to skip using any vitamin A if you’re pregnant, just to be cautious. As in all cases, consult your doctor to find out if tretinoin could be right for you.

Is tretinoin safe to use?

When used properly, tretinoin is perfectly safe. However, due to its potency, users might experience dryness and increased sensitivity to sunlight when they start using tretinoin. To combat this, be sure to up your moisturizing routine and sun protection. It’s also best to start slowly, using tretinoin a few nights a week, then upping your frequency as your skin adjusts. Tretinoin should also not be used excessively or with other actives like acids. This could damage your moisture barrier.

Shanika Hillocks morning routine Image by Michelle Nash

What is the “purge”?

Unfortunately, for many users, the notorious tretinoin purge is real. But it’s not a sign to give up—actually, it’s the opposite! Going through the purge means your skin is adjusting to the treatment and learning how to repair itself.

The first few times you apply tretinoin, your skin is going through more rapid cell turnover than it’s used to. This means all the acne-causing irritants and bacteria are pushed to the surface faster. This leads to inflammation, which causes breakouts. Even if you aren’t using tretinoin to treat breakouts, the resurfacing process might bring latent bacteria to the head, meaning those seeking anti-aging effects might experience the purge, too.

How to Reduce the Purge and Tretinoin Sensitivity

Though there’s not much you can do to stop the purge, resist the temptation to be harsh with your skin. This will only irritate your skin further at such a volatile time. Instead, be as gentle as possible.

Starting slowly with your tretinoin use might reduce the intensity of your purge. If you experience excessive inflammation, you might want to scale down to less frequent use and only use a pea-sized amount. Some ingredients are helpful in soothing the effects of tretinoin, like niacinamide. Niacinamide is a great supplement to your routine because it helps calm irritation while bolstering the effects of your retinoid.

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How to Use Tretinoin in Your Skincare Routine

Deciding whether or not to start tretinoin isn’t the only question. How do you implement tretinoin in your skincare routine? How should you use tretinoin for the best results? Many have asked, and the answer is surprisingly simple.

When you start tretinoin, your skin will be going through a lot, very fast. Be kind to your visage and do everything to make the transition as easy as possible. At the outset of your tretinoin journey, focus on ingredients that won’t strip your skin or cause further irritation. You can also add ingredients that work well alongside your prescription retinoid. And, of course, you’ll have to take your suncare even more seriously. Apply the medicine at night, then slather on sunscreen to protect your light-sensitive skin during the day. Eventually, you can reintroduce ingredients like acids back into your routine—but only when your skin is less sensitive.

If this sounds like you have to rebuild your whole routine, I’m not going to lie: you might. Here’s a guide to choosing tretinoin-friendly products to reinvent your skin routine.

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The Best Tretinoin Products To Add to Your Skincare Routine

Every product is curated with care by our editors and we’ll always give an honest opinion, whether gifted or purchased ourselves. If you buy something through our links, we may earn a small commission at no cost to you.


A good cleanser will keep your skin clean without stripping it of natural oils. Be wary of ingredients like sulfates, perfumes, or alcohol in your cleaner. These will dry out your skin at a time when you need moisture the most. Opt for something gentle but effective that doesn’t contain acids. Also, make sure to cleanse gently with your fingertips. Scrubbing with a facial tool or even a washcloth might be too abrasive while on tretinoin.


Toning can prime your skin with extra hydration, but only if you choose the right one. Skip anything with alcohol, and instead opt for a hydrating and refreshing supplement to your routine. If you’re used to an acid toner, you’re going to have to retire it for a while on tretinoin. Either way, apply your toner, then wait for it to dry before applying tretinoin. You can also load your skin up with moisture during this step by using a gentle, hydrating essence.


To avoid overstimulating your skin while you start tretinoin, most experts suggest saving serums for the morning and using tretinoin at night. Good serums are those that complement the effects of your retinoid. Niacinamide helps soothe irritated skin and protect the skin barrier. Hydrating serums help keep your skin from excessive dryness. And finally, vitamin C serums help facilitate collagen production.


Keeping your skin moisturized is one of the best ways to minimize the side effects of tretinoin, like irritation and dryness. Experts suggest using a stronger moisturizer when you start with tretinoin while being mindful of your skincare type. If you already suffer from dry skin, you’ll want to use a super-rich moisturizer. If you have oilier skin, you still want to step up your hydration game, but it doesn’t have to be as intense. Just make sure you choose products without synthetic fragrances to keep irritation at bay.

When starting out, apply moisturizer directly after applying tretinoin to minimize potential irritation. As your skin adjusts, you can leave tretinoin on for about 20 minutes before following up with a moisturizer.


I cannot express the importance of always applying your sunscreen (liberally!). This is especially true on tretinoin. Retinoids increase your sensitivity to the sun, so any work your tretinoin is doing will immediately be compromised without adequate sun protection. Try clean mineral sunscreens to provide a physical shield between you and the sun. And be sure to reapply throughout the day!

Now that you know how to use tretinoin and have some amazing products to add to your routine, it’s time to glow like never before! Don’t be afraid to experiment and find what works best for your skin. Remember, skincare is a journey, and with tretinoin, you’re bound to see incredible results. Enjoy the process and happy pampering!

Leave a comment below and let us know if you’ve tried tretinoin and what your experience was like. We’d love to hear from you!1